Novel multipurpose buoy for offshore wind profile measurements EOLOS platform faces validation at ijmuiden offshore metmast

Postprint (published version

Noms de colors aplicats als fongs

En aquest treball es recullen els epítets més freqüents aplicats als noms dels fongs que fan allusió als colors. Aquests epítets, en el cas dels macromicets, acostumen a fer referència al color del carpáfor, mentre que en els micromicets indiquen generalment el color de l'esporada o dels pigments que difonen al substrat o medi de cultiu. La 'lista comprèn 187 noms de colors.This work gathers the most frequent epithets applied to the fungi names that refer to colours. In the macromicetes these epithets refer to the carpophor colour, while in micromicetes they indicate the spore mass colour or pigments that are diffused in the culture medium. The relation includes 187 colour names.Este trabajo recoge los epítetos más frecuentes aplicados a los nombres de los hongos que hacen alusión a los colores. Estos epítetos, en el caso de los macromicetos, suelen hacer referencia al color del carpóforo mientras que en los micromicetos indican generalmente el color de la esporada o de los pigmentos que difunden al medio de cultivo. La relación comprende 187 nombres de colores

Repolarization of tumor infiltrating macrophages and increased survival in mouse primary CNS lymphomas after XPO1 and BTK inhibition

Altres ajuts: This work was supported by research funding from the Instituto de Salud Carlos III, Fondo de Investigaciones Sanitarias cofinanced by the European Regional Development Fund (ERDF); Fundación Asociación Española Contra el Cáncer (M.C. and P.A.) and Gilead Fellowships (GLD16/00144, GLD18/00047, F.B). M.C. holds a contract from Ministerio de Ciencia, Innovación y Universidades. S.B. is the recipient of a postdoctoral fellowship from Fundación Alfonso Martin Escudero.Patients diagnosed with primary central nervous system lymphoma (PCNSL) often face dismal outcomes due to the limited availability of therapeutic options. PCNSL cells frequently have deregulated B-cell receptor (BCR) signaling, but clinical responses to its inhibition using ibrutinib have been brief. In this regard, blocking nuclear export by using selinexor, which covalently binds to XPO1, can also inhibit BCR signaling. Selinexor crosses the blood-brain barrier and was recently shown to have clinical activity in a patient with refractory diffuse large B-cell lymphoma in the CNS. We studied selinexor alone or in combination with ibrutinib in pre-clinical mouse models of PCNSL. Orthotopic xenograft models were established by injecting lymphoma cells into the brain parenchyma of athymic mice. Tumor growth was monitored by bioluminescence. Malignant cells and macrophages were studied by immunohistochemistry and flow cytometry. Selinexor blocked tumor growth and prolonged survival in a bioluminescent mouse model, while its combination with ibrutinib further increased survival. CNS lymphoma in mice was infiltrated by tumor-promoting M2-like macrophages expressing PD-1 and SIRPα. Interestingly, treatment with selinexor and ibrutinib favored an anti-tumoral immune response by shifting polarization toward inflammatory M1-like and diminishing PD-1 and SIRPα expression in the remaining tumor-promoting M2-like macrophages. These data highlight the pathogenic role of the innate immune microenvironment in PCNSL and provide pre-clinical evidence for the development of selinexor and ibrutinib as a new promising therapeutic option with cytotoxic and immunomodulatory potential. The online version of this article (10.1007/s11060-020-03580-y) contains supplementary material, which is available to authorized users

Examining the constructs about the supervisor\u27s difficulty scale in supporting the return to work of people with mental health disorders

Within the framework of the multidisciplinary RECS project and with the aim of describing the particle flux transfer from the continental shelf to the deep basin, an array of five mooring lines equipped with a total of five pairs of PPS3/3 sequential-sampling sediment traps and RCM-7/8 current meters were deployed 30 m above the bottom from March 2003 to March 2004 inside and outside the Blanes Canyon. One mooring line was located in the upper canyon at 600 m depth, one in the canyon axis at 1700 m depth and other two close to the canyon walls at 900 m depth. A fifth mooring line was deployed in the continental open slope at 1500 m water depth. The highest near-bottomdownwardparticle flux (14.50 g m-2 d-1)wasrecorded at the trap located in the upper canyon (M1), where continental inputs associated with the presence of the Tordera River are most relevant. On the other hand, the downward fluxes (4.35 g m-2 d-1) in the canyon axis (M2) were of the same order as those found in the western flank (M3) of the canyon. Both values were clearly higher than the value (1.95 g m-2 d-1) recorded at the eastern canyon wall (M4). The open slope (M5) mass flux (5.42 mg m-2 d-1) recorded by the sediment trap located outside the canyon system was three orders of magnitude lower than the other values registered by the inner canyon stations. The relevance of our data is that it explains how the transport pathway in the canyon occurs through its western flank, where a more active and persistent current toward the open ocean was recorded over the entire year of the experiment. Off-shelf sediment transport along the canyon axis showed clear differences during the period of the study, with some important events leading to strong intensifications of the current coupled with large transport of particle fluxes to the deepest parts of the canyon. Such events are primarily related to increases in river discharge and the occurrence of strong storms and cascading events during the winter. In summary, in this study it is shown that the dynamics of thewater masses and the currents in the study area convert the sharp western flank of the Blanes Canyon in a more active region that favors erosion processes than the eastern flank, which has a smoother topography and where the absence of erosional conditions yields to steadier sedimentary processes.Peer ReviewedPostprint (published version

Barcelona Coastal Monitoring with the “Patí a Vela”, a Traditional Sailboat Turned into an Oceanographic Platform

Special issue Technological Oceanography.-- 16 pages, 12 figures, 3 tables.-- Data supporting reported results can be found at https://paticientific.org/index.php/dades/ (accessed on 13 April 2022) and through https://zenodo.org/search (accessed on 13 April 2022) by searching “pati cientific”.Shelf waters near large cities, such as Barcelona, are affected not only by meteorological episodes but also by anthropogenic influence. Scientists usually use data from on-site coastal platforms to analyze and understand these complex water ecosystems because remote sensing satellites have low spatiotemporal resolution and do not provide reliable data so close to the coast. However, platforms with conventional oceanographic instrumentation are expensive to install and maintain. This study presents the scientific adaptation and initial measurements from a “patí a vela”, which is a very popular unipersonal catamaran in Barcelona. This versatile sailing vessel has been adapted to contain several low-cost sensors and instruments to measure water properties. Here, we describe the setup of a multi-parameter prototype, and then focus on results obtained using a low-cost temperature profiler. First, the temperature data are compared and validated with another conventional oceanographic instrument used in monthly oceanographic cruises. Then, field measurements between July and November 2021 are used to explore the relationship between air and water temperature in the Barcelona coastal area, showing the seasonal evolution of the temperature profile. We conclude that citizen sampling from fully sustainable sailing boats may turn into an effective strategy to monitor the urban coastal watersThis work has been carried out within the framework of the 2019 Barcelona Pla de Ciència, with funding from the Barcelona City Council through the project “Development of a citizen monitoring program for the Barcelona coastal waters: the Scientific Patí Vela” (PATI CIENTIFIC; references 19SO1645-006, 19SO1649-006, 19SO1651-006). [...] The ICM authors also recognize the institutional support of the Spanish Government through the Severo Ochoa Center of Excellence accreditation (CEX2019-000928-S)Peer reviewe

Confinament, Oceanografia i Bombolles

La pandèmia que ens té tancats a casa ([1]) m’ha transportat, a estones, a les campanyes oceanogràfiques. Suposo que ho fan les rutines forçades i la delimitació precisa dels ‘dins’ i els ‘fores’, que són tan clars en un vaixell, i que ara també veiem clars a cada casa. Molts dies, a l’hora d’aplaudir la feina dels sanitaris, uns veïns que viuen a peu pla aixequen la porta del garatge i ho fan des del llindar. Podrien fer un pas endavant i aplaudir des de la vorera, però el límit de la casa els és clar i precís, i no el travessen. Com un navegant que percep l’hostilitat de l’aigua i sap que no podria viure gaire estona ‘fora’ d’un vaixell, tots plegats hem percebut el ‘fora’ de les nostres cases com una intempèrie hostil. Amb tristor, amb resignació, amb consciència solidària o simplement obligats, durant unes setmanes no ens hem llençat al carrer sinó que ens hem quedat a casa, on ens envolten les coses que en diem nostres i on convivim –la majoria- amb persones de qui podem dir que, amb el temps, ens hem anat fent els uns als altres. Però encara que estigui situat als antípodes de qualsevol viatge, el confinament m’ha dut a associar la reclusió per quarantena a la reclusió per oceanografia. Voldria estirar-ne el filPeer reviewe

Circulation over a submarine canyon in the NW Mediterranean

18 pages, 14 figuresThe circulation in Blanes canyon, an interruption in the NW Mediterranean continental shelf north of Barcelona, was investigated. The study employs data from oceanographic surveys carried out in the summer and fall of 2003. Velocity data show that in the vicinity of the shelf break the flow is deflected along the canyon walls. A cyclonic mean flow can be seen over the canyon mouth owing to vortex stretching of fluid parcels advected across the shelf break. Field observations are in qualitative agreement with fundamental fluid dynamic considerations based on potential vorticity conservation and friction effects at lateral boundaries. Evidence is given that upwelling is found near the shelf break inside the canyon in the two field experiments. This upwelling extends vertically from the seasonal thermocline (at about 100 in) to the shelf-slope front (at about 200 m). There is no evidence that upwelled water can reach the continental shelf. Copyright 2008 by the American Geophysical UnionM.M.F. acknowledges a Juan de la Cierva postdoctoral fellowship at IMEDEA (CSIC-UIB). This work has been performed in the framework of RECS project (REN2002-04556-C02-01/MAR) funded by the Spanish Ministry of Science, and it was partially funded by the U.S. National Science Foundation under grant OCE-0527940Peer Reviewe

Proposta de millora de la qualitat de les aigües residuals de Sant Martí Sescorts

Diagnòsi de les aigües residuals de sant martí Sescorts i proposta de millora de la qualitat d' aquestes aigues residualsAQUOLOGIST, S.L